Throughout DBM’s 14 plus years in operation, we have designed and performed custom projects for clients when off-the-shelf solutions were not appropriate. We have expertise in several therapeutic areas including renal, respiratory, metabolic, sensory and skin and have worked with myriad cell types in both 2D and 3D tissue culture formats.
If you have a difficult or custom project, please submit a request and we will work with you to help determine feasibility and cost.
Some examples of the projects we have completed are listed below.
- Primary human and animal cell culture establishment and human cell immortalization and cell line creation
- Using immortalized cultures to perform Hit-to-lead and lead asset testing on one-off cell platforms
- In vitro validation of Artificial Intelligence-Derived therapeutics in normal and diseased tissues
- Targeted high-throughput screening in 3D or 2D formats w/ human lung, renal, vascular, and other cell cultures
- Hit-to-lead and lead asset testing with a panel of bioassays in differentiated human adipocytes and other human cells relevant to metabolic diseases
- HTS and validation using ion-sensitive fluorescent probes or voltage-sensitive dyes in intact, living cells at physiological temperatures and in real time