Human Cellular Toxicity Assay Panels

The current ‘gold standard’ for in vitro cell safety vs. toxicity assessment for hit-to-lead or lead assets is the mouse 3T3 fibroblast. In DBM’s view, this is antiquated and insufficient. For all of DBM’s hit-to-lead and lead small molecule assets, we perform the same bioassays that we offer to our customers in the menu-based offerings of our Online Store. We offer basic testing platforms in 2D culture format for a panel of different human tissue-derived primary cell cultures. One or more cell types from each tissue can be tested. Our offerings are menu-driven and, therefore, customizable for each customer.

For similar analysis of additional specialized cell types (hepatocytes, adipocytes, cardiomyocytes, neuronal cells, etc.), please also inquire on Custom Inquiry page for capabilities and more information.

Human Cellular Toxicity Assay Panels
Product
Price
Quantity
 
Human Renal Cell Panel

Includes 2D TC-based assessment of three different primary cultures of human mixed cortical, mixed medullary, and proximal tubule-derived renal epithelial cells.

$3,000.00
Human Lung Cell Panel

Includes 2D TC-based assessment of four different primary cultures of human large airway epithelial cells, small airway epithelial cells, lung microvascular endothelial cells and airway smooth muscle cells.

$4,000.00
Human Vascular Cell Panel

Includes 2D TC-based assessment of four different primary cultures of human arterial Endothelial cells, venous endothelial cells, microvascular endothelial cells and vascular smooth muscle cells.

$4,000.00
Human Skin Cell Panel

Includes 2D TC-based assessment of two different primary cultures of human keratinocytes, melanocytes, and dermal fibroblasts.

$3,000.00
Human Tissue Snapshot Cell Panel

Includes 2D TC-based assessment of primary cultures of human mixed renal epithelial cells, mixed skin cells (keratinocytes, melanocytes and dermal fibroblasts), large airway epithelial cells, and vascular endothelial cells.

$10,000.00

Custom CRO Services Program

DBM has specialty standard operating procedures for the growth of the cells above in 3D formats (in Biogels or on permeable filter supports). Please inquire at our Custom CRO Page about having DBM share these SOPs for a one-time fee and/or for working with DBM as a CRO services outfit using these methods and performing these bioassays for you.

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